This tip came by way of OSXHelp, another great site dedicated to helping you get the most out of your Apple Mac.
We’ve discussed Mac keyboard shortcuts before. Here’s one I didn’t know about. Mac OSX has a built in dictionary which you can access by hovering over a word and pressing Cmd+Control+D key. When you do, a pop-up window appears with the definition of the word.

Pop-up a dictionary with a simple mouse click.